RT Journal Article
SR Electronic
T1 Diarrhoea, weight loss and polyposis: think Cronkhite-Canada syndrome
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr0820114640
DO 10.1136/bcr.08.2011.4640
VO 2011
A1 Elie Aoun
A1 Michelle Victain
A1 Marcia C Mitre
YR 2011
UL http://casereports.bmj.com/content/2011/bcr.08.2011.4640.abstract
AB A 71-year-old male presented with nausea, diarrhoea and weight loss. He had mild to moderate alopecia, paucity of eyebrow hair, erythematous non-pruritic nodular rash on the wrists, toenail onychomychosis and scalp hyperpigmentation. A colonoscopy revealed an irregular, haemorrhagic 5 cm rectosigmoid mass. Biopsies revealed mucin distended glands and focal ischemic changes. A CT scan showed numerous polypoid-like lesions in the stomach. Upper endoscopy showed mucosal erythema and nodularity with polypoid-like lesions. Biopsies showed cystic glandular dilatation, lamina propria oedema and chronic inflammation consistent with Cronkhite-Canada syndrome (CCS). The patient was started on nutrition supplementation. His skin manifestations were treated topically and with mineral supplements. He improved within 10 weeks and is currently asymptomatic. A high index of suspicion for CCS should exist in patients who present with weight loss, diarrhoea and polyposis. If diagnosed early, the disease can be treated with the goal of clinical remission.