RT Journal Article
SR Electronic
T1 Duodenal adenocarcinoma arising from a pyloric gland adenoma with a brief review of the literature
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr1020103385
DO 10.1136/bcr.10.2010.3385
VO 2010
A1 T S Khor
A1 I Brown
A1 J Kattampallil
A1 I Yusoff
A1 M P Kumarasinghe
YR 2010
UL http://casereports.bmj.com/content/2010/bcr.10.2010.3385.abstract
AB Pyloric gland-type adenoma of the duodenum with documented malignant progression is rare. A case is presented of an 87-year-old man with bloating and nausea, who on investigation was found to have a polyp on the anteroinferior wall of the duodenal cap. Histologic examination of the polyp showed features of a pyloric gland adenoma (PGA) demonstrating the full spectrum of progression from low- to high-grade dysplasia and finally invasive adenocarcinoma. The carcinoma showed gastric-type differentiation highlighted by its mucin immunohistochemistry profile and was of advanced stage with lymph node metastasis. The literature on PGAs and the little documentations on progression to carcinoma in duodenal PGAs are reviewed.