TY - JOUR T1 - Duodenal adenocarcinoma arising from a pyloric gland adenoma with a brief review of the literature JF - BMJ Case Reports DO - 10.1136/bcr.10.2010.3385 VL - 2010 SP - bcr1020103385 AU - T S Khor AU - I Brown AU - J Kattampallil AU - I Yusoff AU - M P Kumarasinghe Y1 - 2010/01/01 UR - http://casereports.bmj.com/content/2010/bcr.10.2010.3385.abstract N2 - Pyloric gland-type adenoma of the duodenum with documented malignant progression is rare. A case is presented of an 87-year-old man with bloating and nausea, who on investigation was found to have a polyp on the anteroinferior wall of the duodenal cap. Histologic examination of the polyp showed features of a pyloric gland adenoma (PGA) demonstrating the full spectrum of progression from low- to high-grade dysplasia and finally invasive adenocarcinoma. The carcinoma showed gastric-type differentiation highlighted by its mucin immunohistochemistry profile and was of advanced stage with lymph node metastasis. The literature on PGAs and the little documentations on progression to carcinoma in duodenal PGAs are reviewed. ER -