PT  - JOURNAL ARTICLE
AU  - T S Khor
AU  - I Brown
AU  - J Kattampallil
AU  - I Yusoff
AU  - M P Kumarasinghe
TI  - Duodenal adenocarcinoma arising from a pyloric gland adenoma with a brief review of the literature
AID  - 10.1136/bcr.10.2010.3385
DP  - 2010 Jan 01
TA  - BMJ Case Reports
PG  - bcr1020103385
VI  - 2010
4099  - http://casereports.bmj.com/content/2010/bcr.10.2010.3385.short
4100  - http://casereports.bmj.com/content/2010/bcr.10.2010.3385.full
AB  - Pyloric gland-type adenoma of the duodenum with documented malignant progression is rare. A case is presented of an 87-year-old man with bloating and nausea, who on investigation was found to have a polyp on the anteroinferior wall of the duodenal cap. Histologic examination of the polyp showed features of a pyloric gland adenoma (PGA) demonstrating the full spectrum of progression from low- to high-grade dysplasia and finally invasive adenocarcinoma. The carcinoma showed gastric-type differentiation highlighted by its mucin immunohistochemistry profile and was of advanced stage with lymph node metastasis. The literature on PGAs and the little documentations on progression to carcinoma in duodenal PGAs are reviewed.