TY - JOUR T1 - Melorheostosis and its treatment with intravenous zoledronic acid JF - BMJ Case Reports DO - 10.1136/bcr.04.2009.1757 VL - 2010 SP - bcr0420091757 AU - Rosemary Jane Hollick AU - Alison Black AU - David Reid Y1 - 2010/01/01 UR - http://casereports.bmj.com/content/2010/bcr.04.2009.1757.abstract N2 - We report a case of melorheostosis, a rare bone disorder characterised by mesodermal dysplasia, and its successful and prolonged treatment with the intravenous bisphosphonate zoledronic acid. The middle-aged man presented with pain and swelling of his tibia, which was diagnosed by imaging and bone biopsy as being due to melorheostosis. There was early symptom control after a single infusion of intravenous zoledronic acid. Prolonged symptom relief was accompanied by long-term suppression of the bone resorption marker β cross-laps. We suggest that melorheostosis can be treated with intravenous zoledronic acid and that treatment can be monitored by the use of a specific bone resorption marker. ER -