PT  - JOURNAL ARTICLE
AU  - Feltgen, Nicolas
AU  - Agostini, Hansjuergen
AU  - Auw-Haedrich, Claudia
AU  - Hansen, Lutz L
TI  - Histopathological findings after retinal endovascular lysis in central retinal vein occlusion
AID  - 10.1136/bcr.11.2008.1205
DP  - 2009 Jan 01
TA  - BMJ Case Reports
PG  - bcr1120081205
VI  - 2009
4099  - http://casereports.bmj.com/content/2009/bcr.11.2008.1205.short
4100  - http://casereports.bmj.com/content/2009/bcr.11.2008.1205.full
AB  - This case study explores the histopathological findings 9 months after retinal endovascular lysis (REVL) in a 62-year-old woman having a 7-week-old, highly ischaemic central retinal vein occlusion (CRVO) with hand movement vision. Angiographic examination 3 days postoperatively did not show improved arteriovenous passage time. In addition, the patient’s postoperative vision did not change, and despite intensive photocoagulation and cryotherapy in the early postoperative period, the globe had to be removed 9 months later because of painful phthisis. Histological findings at the site of puncture were epiretinal membrane, interrupted internal limiting membrane and thickened venous wall. This is the first case to show the histological changes after surgical REVL in a human eye. In this case, REVL did not prevent neovascular glaucoma despite successful recombinant tissue plasminogen activator (rt-PA) injection in a venous branch close to the papilla. It was concluded that rt-PA injection after 7 weeks of CRVO is too late.