RT Journal Article
SR Electronic
T1 Corneal rupture in a child with Down syndrome and hyperthyroidism
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr0820080842
DO 10.1136/bcr.08.2008.0842
VO 2009
A1 Sasha Howard
A1 Joseph Raine
A1 Mehul Dattani
YR 2009
UL http://casereports.bmj.com/content/2009/bcr.08.2008.0842.abstract
AB The present report describes the clinical findings in a rare case of a child with trisomy 21 and hyperthyroidism, who developed severe acute hydrops with corneal perforation secondary to underlying keratoconus. There is a known association between trisomy 21 and keratoconus (a conic protrusion of the cornea),1 and children with trisomy 21 are also at increased risk of developing thyroid disease, including thyrotoxicosis with exophthalmos.2,3 However, a paediatric case with dual underlying diagnoses of trisomy 21 and hyperthyroidism, who subsequently developed severe hydrops, has not to our knowledge been previously described.