RT Journal Article SR Electronic T1 Rapid improvement of diffusion-weighted imaging abnormalities after glucose infusion in hypoglycaemic coma JF BMJ Case Reports FD BMJ Publishing Group Ltd SP bcr0720080514 DO 10.1136/bcr.07.2008.0514 VO 2009 A1 J Maruya A1 H Endoh A1 H Watanabe A1 H Motoyama A1 H Abe YR 2009 UL http://casereports.bmj.com/content/2009/bcr.07.2008.0514.abstract AB Diffusion-weighted imaging (DWI) may detect hyperintense lesions in patients with transient hypoglycaemia-induced hemiparesis or coma, which are completely reversible after glucose infusion.1–3 In vivo animal studies have documented the visualisation of such hypoglycaemia-induced changes of signal intensity and the reversal by glucose intake in detail.4 However, the time necessary for hyperintense lesions on DWI to disappear after glucose infusion in humans is still unclear. A 54 year old woman presented comatose with brain stem signs and severe hypoglycaemia. DWI demonstrated hyperintense lesions in the corpus callosum and internal capsules. She was treated with IV glucose. These lesions had resolved significantly on imaging 2 hours later and completely resolved on repeat imaging 2 days later. This report documents the time course of recovery of neurological lesions induced by hypoglycaemia after treatment with IV glucose.