PT  - JOURNAL ARTICLE
AU  - P Striano
AU  - Andrea Elefante
AU  - Antonietta Coppola
AU  - Fabio Tortora
AU  - Federico Zara
AU  - Carlo Minetti
TI  - Dramatic response to levetiracetam in post-ischaemic Holmes’ tremor
AID  - 10.1136/bcr.08.2008.0643
DP  - 2009 Jan 01
TA  - BMJ Case Reports
PG  - bcr0820080643
VI  - 2009
4099  - http://casereports.bmj.com/content/2009/bcr.08.2008.0643.short
4100  - http://casereports.bmj.com/content/2009/bcr.08.2008.0643.full
AB  - Holmes’ tremor refers to an unusual combination of rest, postural and kinetic tremor of extremities. Common causes of Holmes’ tremor include stroke, trauma, vascular malformations and multiple sclerosis, with lesions involving the thalamus, brain stem or cerebellum. Although some drugs (eg, levodopa and dopaminergic drugs, clonazepam and propranolol) have been occasionally reported to give some benefit, medical treatment of Holmes’ tremor is unsatisfactory, and many patients require thalamic surgery to achieve satisfactory control. We report a patient in whom post-ischaemic Holmes’ tremor dramatically responded to levetiracetam treatment.