342 e-Letters

  • Unexpected Untoward Effect of Evidence-Based Medicine
    Taopheeq B. Rabiu

    Dear Editor

    The report by Fremault and Rodenstein1 is a significant contribution to our knowledge of the hazards posed by generalization rather than individualization of patient care. While there is no doubt that evidence- based medicine(EBM) has come to stay in health care services and that that the practice has helped to reduce cost of health care services by avoiding a waste of efforts and resources, complete adh...

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  • Loss of heterozygosity in SDHB locus on chromosome 1 in a subject with a metastatic papillary type I
    Dr. Umasuthan Srirangalingam
    A recent case report in this journal presented the case of a subject with an SDHB mutation who developed a metastatic type II papillary renal cell carcinoma which therapeutically responded to the tyrosine kinase inhibitor, sunitinib 1 2. SDHB germline mutations account for the familial paraganglioma syndrome type 4 (PGL-4) which is characterised by predominantly extra-adrenal paragangliomas with high malignant potential 2. SDHB...
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