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A 5-year-old boy presented with fever for 4 days and acute-onset weakness of the right upper and lower limb for 1 day. There was no history of headache, seizures, vomiting and altered sensorium, rash or bleeding from any site. On examination, he had normal mentation, neck stiffness, Kernig’s sign, right-sided upper motor neuron facial palsy and right hemiparesis. The rest of the systemic examination was unremarkable. A clinical diagnosis of acute meningitis with left Middle Cerebral Artery (MCA) territory stroke was made.
Cerebrospinal fluid examination revealed 980 cells/µL (90% polymorphonuclear leucocytes and 10% lymphocytes), glucose 47 mg/dL, proteins 110 mg/dL and Neisseria meningitides antigen was positive; however, no organism could be isolated on microscopy and culture. He was unimmunised for meningococcal vaccine. Blood culture was sterile. Detailed stroke and immune deficiency work-up was negative. MRI of the brain showed altered signal changes in left frontal lobe, anterior limb of the internal capsule, left caudate head and putamen (figure 1). MR angiography of intracranial vessels revealed attenuated left middle cerebral artery flow voids (figure 2). The child was started on intravenous ceftriaxone and oral aspirin in antithrombotic doses. At 6 months follow-up, he was asymptomatic and had no weakness.
Bacterial meningitis is a serious infection of central nervous system and N meningitides is one of the the most common aetiologies. Focal neurological deficit is seen in 5%–14% patients, and it results from vasculitis, transient vasospasm and septic thrombosis of intracranial arteries, cortical veins and dural venous sinuses, leading to the infarction of cerebral territories.1 Vascular involvement in meningococcal meningitis secondary to vasospasm resulting from subarachnoid inflammation or vasculitis is rarely described in children; however, there are anecdotal reports in adults.2 The radiological findings in index patients were suggestive of secondary vasculopathy pattern and it may be secondary to the underlying meningococcal meningitis. Post-meningitis vascular events usually present within the first week of illness and are commonly seen with Streptococcus pneumoniae, N meningitides, Haemophilus influenzae and Mycobacterium tuberculosis.3 The treatment of vasculopathy includes oral aspirin in antithrombotic doses and heparin may be more effective in recurrent strokes or infarction. To conclude, acute-onset focal neurological deficit in a child with acute bacterial meningitis should raise a suspicion of cerebral vasculopathy.
Bacterial meningitis is a serious infection of central nervous system and Neisseria meningitides is one of the most common underlying aetiology.
Post-meningitis vascular events are rare and usually present within the first week of illness and are commonly seen with Streptococcus pneumoniae.
The treatment of vasculopathy includes oral aspirin in antithrombotic doses and heparin may be more effective in recurrent strokes or infarction.
Contributors IKS: patient management, analysis of radiological data, literature review and initial draft manuscript preparation. VS and SK: patient management, literature review and initial draft manuscript preparation. LS: clinician-in-charge, critical review of manuscript for important intellectual content and final approval of the version to be published.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Parental/guardian consent obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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