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A 59-year-old man was admitted with 3 weeks of worsening shortness of breath 18 months after receiving a bilateral lung transplant for idiopathic pulmonary fibrosis. His immunosuppression included tacrolimus, everolimus and low-dose prednisone with no antifungal prophylaxis at the time of admission. CT chest revealed multiple, bilateral pulmonary nodules (figure 1—red arrows). CT-guided biopsy revealed fungal hyphae (figure 2). The initial CT and ultrasound of the neck at the onset of sore throat was negative; however, repeat CT neck for evolving neck pain and dysphasia during hospital course showed a mass-like lesion in the right thyroid lobe with extensive surrounding inflammatory changes (figure 3—green arrow). The lesion was also visualised on ultrasound, where it appeared as a hypoechoic solitary nodule (figure 4). Laboratory evaluation revealed hyperthyroidism, with a Thyroid Stimulating Hormone (TSH) of <0.01 µIU/mL (normal: 0.35–4.94 µIU/mL) and a free T4 of 2.72 ng/dL (normal: 0.70–1.48 ng/dL). The patient was initiated on dual antifungal therapy with liposomal amphotericin and posaconazole, resulting in rapid resolution of neck pain. However, repeat CT neck 2 weeks after revealed a thyroid abscess in the right lobe, and subsequently the patient underwent right thyroid lobectomy and isthmusectomy. Surgical debridement of the thyroid abscess revealed fungal hyphae; thus, confirming the diagnosis of fungal thyroiditis (figure 5). A specific fungal pathogen was never successfully cultured from our patient. He was treated for presumed Aspergillus infection, the most common etiology of fungal thyroiditis, with clinical improvement.1
Thyroiditis is a rare manifestation of disseminated fungal infection in immunocompromised hosts.
Aspergillus spp are the most commonly implicated pathogen, although there are reports of cases due to Cryptococcus neoformans, Histoplasma capsulatum, Coccidioides immitis and Candida spp.
Antifungal therapy targeting the culprit organism and consideration of surgical debridement are the mainstays of treatment.
Haresh Mani, MD Min Kim, MD.
Contributors CK, SK and AWB: planning, writing, revision. SC: planning, revision.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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