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Influenza A: another cause of SIADH?
  1. Simon Mifsud1,
  2. Maria Alessandra Zammit2,
  3. Ramon Casha2,
  4. Claudia Fsadni2
  1. 1Department of Medicine, Mater Dei Hospital, Msida, Malta
  2. 2Department of Medicine, Infectious Diseases Division, Mater Dei Hospital, Msida, Malta
  1. Correspondence to Dr Simon Mifsud, mifsudsimon{at}


The syndrome of inappropriate antidiuretic hormone (SIADH) secretion is a frequent cause of hyponatraemia. It is a dilutional hyponatraemia secondary to impaired urinary dilution in the absence of renal disease or any identifiable non-osmotic stimulus known to induce antidiuretic hormone secretion. SIADH can arise secondary to various respiratory tract infections; however, the association between SIADH and influenza A infection is described in only a few cases in the literature. The authors present a case report of influenza A that may have caused a profound SIADH-related hyponatraemia.

  • endocrinology
  • metabolic disorders
  • influenza

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  • Contributors SM was responsible for literature review and manuscript preparation. MAZ, RC and CF contributed towards editing and review of the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.