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Interstitial lung disease and inflammatory myopathy in antisynthetase syndrome with PL-12 antibody
  1. Ameen Jubber1,
  2. Mudita Tripathi1,
  3. James Taylor2
  1. 1Rheumatology, Northampton General Hospital NHS Trust, Northampton, UK
  2. 2Rheumatology, Northampton General Hospital NHS Trust, Northampton, UK
  1. Correspondence to Dr Ameen Jubber, Ameenjubber1{at}


We report the case of an 80-year-old Caucasian man with PL-12 antibody positive antisynthetase syndrome. He presented with progressive dyspnoea and weight loss, later developing dysphagia, mild proximal muscle weakness and mild sicca symptoms. Investigations revealed interstitial lung disease, inflammatory myopathy and an immunology profile consistent with PL-12 antisynthetase syndrome. Prednisolone and cyclophosphamide resulted in a significant improvement of all his symptoms.

  • connective tissue disease
  • sjogren’s syndrome
  • musculoskeletal syndromes
  • muscle disease

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  • Contributors AJ, MT and JT conceived of the presented idea. AJ wrote the manuscript with support from MT and JT.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.