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CASE REPORT
Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation
  1. Rohan Bir Singh1,
  2. Priti Batta2
  1. 1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
  2. 2Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York City, New York, USA
  1. Correspondence to Dr Rohan Bir Singh, dr.rohandhaliwal{at}gmail.com and Priti Batta, pbatta{at}nyee.edu

Summary

A 36-year-old male, soft contact lens wearer was referred by his primary ophthalmologist for corneal ulcer of the right eye (OD), which was persistent despite topical fluoroquinolone therapy for 1 month. A ring-shaped infiltrate typically seen in Acanthamoeba infection was noted, and topical therapy with chlorhexidine and polyhexamethylene biguanide was initiated. However, the patient’s condition deteriorated over the next several weeks; thus, diagnostic and therapeutic penetrating keratoplasty was performed. The postoperative immunohistochemical analysis suggested a diagnosis of herpes simplex virus (HSV) keratitis. The patient ultimately improved after initiation of oral valacyclovir following penetrating keratoplasty. We report a case of a commonly encountered clinical entity, HSV keratitis, with an atypical clinical presentation, masquerading as Acanthamoeba keratitis.

  • ophthalmology
  • anterior chamber
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Footnotes

  • Contributors RBS authored the manuscript. PB diagnosed and managed the patient, provided the images for the case and edited the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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