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Large mediastinal mass in a 15-year-old boy
  1. Mariyam Gohar Ali1,
  2. Ali Bin Sarwar Zubairi1,
  3. Farah Naz Qamar2
  1. 1Pulmonary Medicine, Aga Khan University Hospital, Karachi, Pakistan
  2. 2Paediatric Infectious Disease, Aga Khan University Hospital, Karachi, Pakistan
  1. Correspondence to Dr Mariyam Gohar Ali, maryamali.86{at}


Hyperimmunoglobulin E syndrome is a rare multisystem inherited disorder characterised by high serum IgE levels, skin disorder causing eczema, dermatitis, recurrent staphylococcal infections and pulmonary infections and various skeletal and connective tissue abnormalities. Common presentation is with recurrent skin and sinopulmonary infections. Several features unrelated to immune system such as characteristic facial features, hyperextensibility of joints, multiple bone fractures and craniosynostosis have been described in the literature. We describe a rare presentation of this disease with invasive aspergillosis presenting as mediastinal mass with extension to mediastinal structures and pulmonary vasculature.

  • dermatology
  • immunology
  • pneumonia (infectious disease)

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  • Contributors MGA performed the literature search and wrote the manuscript. ABSZ and FNQ reviewed the manuscript and the case.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.