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Verruciform xanthoma overlying inflammatory linear verrucous epidermal nevus and in broad segmental distribution
  1. Sanjay Singh1,
  2. Sujay Khandpur1,
  3. Shipra Agarwal2
  1. 1Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
  2. 2Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
  1. Correspondence to Sujay Khandpur, sujay_khandpur{at}


A 17-year-old woman presented with moderately itchy, non-progressive, linearly arranged verrucous plaques over dorsum of left foot since early childhood. Two years ago, she developed slowly increasing, verrucous exophytic growth in posterior most aspect of linear verrucous plaque. One year ago, she also developed multiple, linearly arranged, fleshy plaques with surface crusting over lateral aspect of right leg extending to thigh. Biopsy from both verrucous lesion on left foot and fleshy plaque on right leg showed an exophytic growth with significant papillomatosis, neutrophils in stratum corneum, acanthosis and infiltration of papillary dermis with foamy macrophages that were CD 68 positive, features compatible with verruciform xanthoma (VX). Biopsy from linear verrucous plaque over left foot was consistent with inflammatory linear verrucous epidermal nevus (ILVEN). A diagnosis of segmental VX and VX overlying ILVEN was made.

  • dermatology
  • pathology

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  • Contributors SS wrote the manuscript. Histopathological evaluation was done by SA and SK. SK edited and gave final approval.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.