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Comorbid presentation of syringomyelia and Guillain-Barre syndrome, attributed to mycoplasma, in a 6-year-old female patient
  1. Olga Vampertzi1,
  2. Efterpi Dalpa1,
  3. Theofanis Vavilis2,
  4. Despoina Tramma1
  1. 14th Department of Pediatrics, Geniko Nosokomeio Thessalonikis Papageorgiou, Thessaloniki, Greece
  2. 2Laboratory of Physiology, Department of Physiology and Pharmacology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
  1. Correspondence to Dr Olga Vampertzi, olgatrieste{at}


Syringomyelia is the development of a fluid-filled cavity or syrinx within the spinal cord that can cause loss of sensation and muscle spasticity. Guillain-Barre syndrome (GBS) is a postinfection autoimmune disease, classified as an acute polyneuropathy. This report describes the emergency admission of a 6-year-old girl presenting with sudden pallor and pain in both lower limbs. The patient’s reflexes were normal, as were the results of her sonography, radiography and biochemical tests; however, spinal MRI revealed extensive compartmentalised syringomyelia extending from C2 to T3. A sensory and motor nerve conduction study revealed a demyelinating type motor polyneuropathy which, along with positive Mycoplasma pneumoniae test, was suggestive of GBS. Intravenous immunoglobulin infusion showed excellent results. In conclusion, we report a rare paediatric case of syringomyelia coexisting with GBS. It is important to bear in mind the possibility of other coexisting diseases even if MRI reveals definitive characteristics of another condition.

  • neurology
  • infection (neurology)
  • peripheral nerve disease
  • paediatrics
  • congenital disorders
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  • Contributors OV has treated the medical case and has drafted the manuscript. ED has treated the case and contributed drafting the manuscript. TV has been a consultant in the pathophysiology of Gullain-Barre syndrome, has contributed drafting the manuscript and has reviewed the manuscript. DT has treated the case and provided corrections and support for the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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