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Thrombocytopenia-associated multiple-organ failure (TAMOF): recognition and management
  1. Musaab Ramsi,
  2. Alyaa Saeed Al Ali
  1. Paediatric Critical Care Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
  1. Correspondence to Dr Musaab Ramsi, musaab.ali{at}


Thrombocytopenia-associated multiple-organ failure (TAMOF) is an increasingly fatal phenomenon that may be associated with sepsis. TAMOF results from immune dysregulation and impaired activity of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif, member 13. Early recognition of this premorbid condition and specific management results in a significantly improved outcome. Herein, we report the presentation and management of a 2-year-old child with TAMOF who was successfully treated with plasma exchange and recovered without long-term sequelae.

  • paediatric intensive care
  • acute renal failure
  • mechanical ventilation
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  • Contributors MR contributed substantially to the writing and revising the manuscript. AAA contributed to acquisition and interpretation of the case report, and writing the presentation.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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