Article Text

Download PDFPDF
Epstein-Barr-positive classical Hodgkin lymphoma-associated haemophagocytic lymphohistocytiosis: a rare case
  1. Alfredo Iardino1,
  2. Zain Amar2,
  3. Yasir Ahmed3
  1. 1Department of Internal Medicine, Texas Tech University Health Science Center at the Permian Basin, Odessa, Texas, USA
  2. 2Medical Center Hospital, Odessa, Texas, USA
  3. 3Department of Infectious Diseases, Texas Tech University Health Science Center at the Permian Basin, Odessa, Texas, USA
  1. Correspondence to Dr Alfredo Iardino, alfredo.iardino{at}


Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, which is usually triggered by autoimmune disorders, viral infections and malignancy, like lymphomas. We present a 60-year-old Hispanic woman with a medical history of hypertension and systemic lupus erythematosus presenting with fever, generalised weakness and shortness of breath for 3 weeks. She was hypotensive on presentation, and a CT scan of abdomen/chest showed multiple irregular hepatic and splenic hypodense lesions. A liver biopsy revealed Classical Hodgkin lymphoma (cHL) with positive Epstein-Barr virus (EBV) staining that was later confirmed with high serum EBV DNA levels. Incidentally, a liver biopsy disclosed haemophagocytosis in some cells. HLH-associated cHL is an uncommon condition that can cause severe systemic symptoms acting as the perfect mimic of septic shock, deviating the clinical eye toward treating with antibiotics and not addressing in a timely manner the real aetiology of the patient’s condition.

  • heart failure
  • mechanical ventilation
  • haematology (incl blood transfusion)
  • intensive care
View Full Text

Statistics from


  • Twitter @AlfredoIardinoS

  • Contributors AI: writing of manuscript, editing of manuscript, assemble of images, final approval of manuscript, table creator, and chart review. ZA: case presentation writing. YA: editing of manuscript, final approval of manuscript; senior advisor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.