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A case of deadly panniculitis
  1. Carlo Yuson1,
  2. Corinne Maiolo2,
  3. Pravin Hissaria1
  1. 1Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, South Australia, Australia
  2. 2Dermatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
  1. Correspondence to Dr Carlo Yuson, chino.yuson{at}


While the majority of panniculitides are benign in nature, there are rare instances when panniculitis presents as the initial sign of a complex disease state. We describe a case of panniculitis initially diagnosed as lupus profundus that was challenged when features of haemophagocytic lymphohistiocytosis became apparent. We illustrate how some key clinical features and newer investigations can help differentiate between benign and malignant panniculitis.

  • immunology
  • haematology (incl blood transfusion)
  • systemic lupus erythematosus

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  • Contributors All of the authors listed have contributed significantly to this manuscript and are in agreement with its contents. Specifically, CY, CM and PH were all involved with direct management of the patient. In preparing of this manuscript, all three authors agreed upon the salient features of the case. CY was the lead author and created the first and final draft. CM contributed and edited the dermatological aspects of the case, including dermatological descriptions and parts of the discussion. PH was the overall adviser for the case and was involved in the final editing of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Disclaimer This case presentation has not been published previously nor has it been submitted to any other publications.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.