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Large cell neuroendocrine carcinoma and adenocarcinoma of gallbladder with concomitant hepatitis C infection
  1. Sarthak Soin1,
  2. Bibek Singh Pannu1,
  3. Phyo Thazin Myint1,
  4. Amandeep Singh Dhillon2
  1. 1Internal Medicine, Presence Saint Joseph Hospital Chicago, Chicago, Illinois, USA
  2. 2Internal Medicine, Rosalind Franklin University of Medicine and Science Chicago Medical School, North Chicago, Illinois, USA
  1. Correspondence to Dr Sarthak Soin, sarthaksoin{at}


Neuroendocrinetumour (NET) of the gallbladder is an extremely rare tumour and with coexisting adenocarcinoma an even rarer occurrence. Mixed NETs have the tendency to invade the lymph nodes and the hepatic tissue from their high malignant potential, leading to poor prognosis. Survival rates of the patients with mixed NET can be improved with wide excision, adjuvant chemotherapy and radiation. We present a case of 62-year-old woman with history of hepatitis C infection, a risk factor for both hepatic and extrahepatic gastrointestinal malignancies. Patient underwent exploratory laparotomy with resection of the gallbladder and partial hepatectomy. Pathology showed high-grade larger cell neuroendocrine carcinoma 5×4×3 cm along with two separate lesions found out to be adenocarcinomas. In our patient, hepatitis C infection can be an inciting factor for the development of these carcinomas. We will discuss the presentation, treatment modalities and outcomes with this kind of coexisting tumours.

  • hepatitis C
  • endocrine cancer
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  • Contributors SS was involved in writing the first draft and BSP, PTM and ASD were involved in conception and design, acquisition of data or analysis and interpretation of data, and revising them critically for important intellectual context.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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