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Rare cause of manic period trigger in bipolar mood disorder: testosterone replacement
  1. Gulcin Elboga1,
  2. Zeynel Abidin Sayiner2
  1. 1Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey
  2. 2Department of Endocrinology and Metabolism, School of Medicine, Gaziantep University, Gaziantep, Turkey
  1. Correspondence to Dr Zeynel Abidin Sayiner, zeynelasayiner{at}


Hypogonadotropic hypogonadism is a rare congenital disorder characterised by the deficiency and the absence of puberty and infertility. It is caused by the deficient production, secretion or action of gonadotropin-releasing hormone, which is the master hormone regulating the reproductive axis. Gonadotropin-releasing hormone or gonadotropin injections and testosterone replacement therapy are required in the treatment of this disorder. Psychiatric symptoms and disorders may be seen with the use of anabolic androgenic steroids. In this case report, we present a case report in which a patient had behavioural symptoms in childhood and develops bipolar disorder after testosterone replacement therapy. This patient was reached to the remission by increasing the doses of psychiatric drugs without interfering with hormonal therapy. It should be considered that patients receiving testosterone replacement therapy may develop bipolar disorder or trigger mood changes in bipolar mood disease, so behavioural and mood state changes should be closely followed in patients who have bipolar mood disease.

  • psychiatry (drugs and medicines)
  • unwanted effects / adverse reactions
  • bipolar I iisorder
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  • Contributors GE collected the data and wrote the article. ZAS submitted and revised the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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