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Disseminated nocardiosis with infective endocarditis of a transplanted heart
  1. Antonious Ziad Hazim1,
  2. André Martin Mansoor2
  1. 1School of Medicine, Oregon Health and Science University, Portland, Oregon, USA
  2. 2Department of Internal Medicine, Oregon Health and Science University, Portland, Oregon, USA
  1. Correspondence to Dr André Martin Mansoor, mansooan{at}


Nocardiosis is caused by various species of Nocardia and typically occurs as an opportunistic infection. It frequently disseminates, most often involving the lungs, subcutaneous tissues and central nervous system. It has rarely been reported to affect native heart valves. We report the case of a 64-year-old man with disseminated nocardiosis involving the brain, lungs, muscle and tricuspid valve of a transplanted heart. Following antimicrobial therapy, the patient improved clinically and there was no evidence of residual infection on follow-up imaging. This case highlights the presentation of nocardiosis, current therapeutic guidelines and the question of prophylaxis against Nocardia in immunocompromised patients.

  • valvar diseases
  • TB and other respiratory ionfections
  • infection (neurology)
  • immunology
  • transplantation

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  • Contributors Both authors were involved in writing the case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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