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Hungry bone syndrome secondary to prostate cancer successfully treated with radium therapy
  1. Vishnu Vardhan Garla,
  2. Sohail Salim,
  3. Karthik Reddy Kovvuru,
  4. Angela Subauste
  1. Department of Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
  1. Correspondence to Dr Vishnu Vardhan Garla, vishnu.garla{at}


A 50-year-old man with a history of prostate cancer with extensive bone metastasis and hypocalcaemia presented with muscle aches and cramps. Physical exam was significant for Chvostek’s and Trousseau’s sign. Laboratory assessment was consistent with profound hypocalcaemia. This was believed to be due to hungry bone syndrome secondary to advanced prostate cancer. He was treated with intravenous calcium, vitamin D and calcitriol. He also received three doses of radium223 therapy. After therapy, hypocalcaemic episodes resolved. Follow-up after 2.5 years showed continued resolution of hypocalcaemia.

  • endocrine system
  • calcium and bone
  • prostate cancer
  • radiotherapy

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  • Contributors VVG was involved in writing the case description. SS and KRK were involved in writing the discussion section. AS is the senior author involved in editing the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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