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Intrahepatic sarcomatoid cholangiocarcinoma
  1. Sara Sintra1,
  2. Rui Costa2,
  3. Carlos Filipe1,
  4. Adélia Simão1
  1. 1Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  2. 2Radiology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  1. Correspondence to Dr Sara Sintra, saranevessintra{at}


Sarcomatoid carcinoma is a rare tumour composed of intermingled malignant epithelial and mesenchymal cells, and it has been reported in various organs including the liver. Sarcomatoid cholangiocarcinoma (CCC) is an extremely rare liver primary tumour. Here, we report a case of an elderly man who was admitted to our hospital after head trauma. He performed a head CT that diagnosed cerebral metastasis. On abdominal CT, he presented a 10×8×9 cm-sized hypodense liver mass in the VII and VIII segments, with peripheral enhancement. Histological and immunohistochemical examination of the tumour showed a malignant neoplasm with both carcinomatous and sarcomatous components and positive expression of cytokeratin and vimentin antibodies. The patient was diagnosed with intrahepatic sarcomatoid CCC at an advanced stage and died 45 days after the diagnosis. We emphasise the importance of immunohistochemistry which may provide a clue to proper diagnosis.

  • liver disease
  • hepatic cancer
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  • Contributors SNS wrote the article. RC helped with the design of the work, data collection and analysis and interpretation of the images. CF helped with the analysis and interpretation of data as well as the drafting of the article. AS also helped with the analysis and interpretation of data and the drafting of the article and made a critical revision of the article. All authors approved the version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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