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Long-term complete remission of a patient with high grade neuroendocrine carcinoma of ampulla of Vater
  1. Farzad Taghizadeh-Hesary,
  2. Afshin Moradi,
  3. Mona Malekzadeh
  1. Radiation-Oncology Department, Shohada-e Tajrish Hospital, Tehran, Iran
  1. Correspondence to Dr Mona Malekzadeh, Farzad_th89{at}


We describe a case report of a 53-year-old man with a 5-months history of progressive jaundice and upper abdominal pain. The patient was further evaluated and finally diagnosed with a high-grade ampullary neuroendocrine tumour (based on endoscopic-guided biopsy). Thereafter, he underwent pancreatoduodenectomy and adjuvant platinum-based chemotherapy. This extremely rare case presents his long-lasting disease-free survival compared with similar cases; this case report exemplifies a new, potentially efficient method for treating high-grade papillary neuroendocrine tumour and may pave the way for further clinical trials utilising this blueprint in the treatment of related conditions.

  • small intestine cancer
  • chemotherapy

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  • Contributors FT-H provided the data and writing the letter. AM provided the pathology data. MM edited the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.