Article Text
Unexpected outcome (positive or negative) including adverse drug reactions
CASE REPORT
Levosulpiride-induced neuroleptic malignant syndrome in rheumatoid arthritis
Summary
A 53-year-old woman, known case of diabetes mellitus and rheumatoid arthritis, presented with a 4-day history of hyperthermia, rigidity, tremor and altered sensorium. She developed these symptoms after having been administered parenteral levosulpiride to control vomiting due to secondary adrenal insufficiency. We managed her as a case of life-threatening neuroleptic malignant syndrome (NMS) requiring mechanical ventilation, bromocriptine and other supportive care. She subsequently recovered and was discharged in a stable condition. To the best of our knowledge, this is the first documented case report describing levosulpiride-induced NMS.
- unwanted effects / adverse reactions
- gastrointestinal system
- drug misuse (including addiction)