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Endometrial metastasis of primary malignant melanoma of the brain
  1. Jessica Little,
  2. Kathleen Braniff
  1. Obstetrics and Gynaecology, Mackay Base Hospital, Mackay, Queensland, Australia
  1. Correspondence to Dr Jessica Little, jessica.little1{at}


Endometrial metastatic malignant melanoma is a rare occurrence from any primary site. A literature search has revealed only 15 reported cases in existing literature, majority of which originated from a primary cutaneous lesion. This is a case of endometrial metastasis of primary malignant melanoma of the brain, the first reported case of its kind. The rarity of endometrial metastatic melanoma may incline clinicians to neglect the importance of malignant melanoma in a patient’s history when they present with abnormal uterine bleeding. However, with increasing rates of primary malignant melanoma, it is likely that the incidence of metastasis to rare sites, such as the endometrium, is also likely to increase. For those women with metastatic disease confined to the uterus, total abdominal hysterectomy +/-bilateral salpingo-oophorectomy improved prognosis considerably. Newer BRAF molecular testing and targeted adjuvant therapy may also significantly improve prognosis in addition to surgical resection and should be considered.

  • cancer - see oncology
  • gynecological cancer
  • skin cancer
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  • Contributors JL: obtaining patient history, discussion of case and history with patient, gaining informed consent from patient, drafting manuscript, critical review of manuscript, revision of manuscript. KB: obtaining patient history, gaining informed consent from patient, critical review of manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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