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Idiopathic nodular glomerulosclerosis (ING) in an African American (AA) man with hepatitis C
  1. Nirmal K Onteddu1,
  2. Jayasri Duggirala2,
  3. Anand C Reddy1,2
  1. 1Internal Medicine, Texas Tech University Health Sciences Center at Permian Basin, Odessa, Texas, USA
  2. 2Permian Basin Kidney Center, Odessa, Texas, USA
  1. Correspondence to Dr Nirmal K Onteddu, nkumarreddyo{at}


Idiopathic nodular glomerulosclerosis (ING) in a non-diabetic patient is uncommon. Nodular glomerulosclerosis is hallmark sign of diabetic nephropathy. ING is a very rare clinicopathological disease associated with smoking, obesity and hypertension, chronic obstructive pulmonary disease and metabolic syndrome. A 68-year-old non-obese African American man with hypertension, smoking and history of hepatitis C presented to the clinic with progressive worsening of lower extremity oedema and declining renal function over few months. Renal biopsy demonstrated nodular glomerulosclerosis. In this case, ING is hypothesised to be associated with hepatitis C along with smoking and hypertension (HTN). We present this case to speculate the existence of yet unknown aetiologies of ING.

  • hypertension
  • chronic renal failure
  • nephrotic syndrome
  • proteinurea
  • hepatitis c
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  • Contributors All authors contributed to the revision and approval of the manuscript. JD and NKO drafted the manuscript. All authors collected data, revised the manuscript and edited the images. NKO is the article guarantor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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