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Anaphylactic shock perioperative to patent blue dye
  1. João Pedro Azevedo,
  2. Marta Alves,
  3. Carmelita Ribeiro,
  4. Ana Todo Bom
  1. Immunoallergy, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal
  1. Correspondence to Dr João Pedro Azevedo, jplazvdo{at}


Patent blue is one of the most used dyes for the identification of sentinel lymph nodes in breast cancer. This report describes a case of an anaphylactic shock reaction to patent blue dye in a patient with cross-reactivity to methylene blue. Therefore, after allergy confirmation, the operation was repeated avoiding blue dye and an alternative labelling technique with 99mTc albumin nanocolloids was used.

  • anaesthesia
  • medical management
  • intensive care
  • immunology
  • healthcare improvement and patient safety
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  • Contributors Skin tests were performed by CR and JPA. JPA and MA did the literature review and JPA was the main writer. ATB was the supervisor and elaborated the main take home messages. All authors approved the final version of the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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