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CASE REPORT
Amyloidosis: a unifying diagnosis for nephrotic syndrome and congestive cardiac failure
  1. Jaskanwal Deep Singh Sara1,
  2. Ryan Khodadadi2,
  3. Dylan Barth3,
  4. Mary Caroline Burton2
  1. 1Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
  2. 2Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
  3. 3Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Jaskanwal Deep Singh Sara, sara.jaskanwal{at}mayo.edu

Summary

Diagnosing patients simply with heart failure or nephrotic syndrome is insufficient, and clinicians should always search for the underlying causes of these syndromes. Amyloidosis represents a rare group of diseases in which abnormal protein, namely amyloid fibrils, build up in various organs. Presentation depends on which organ systems are involved, and symptoms could include breathlessness associated with fluid overload suggestive of cardiac and/or renal involvement and diarrhoea and weight loss, suggestive of gastrointestinal involvement. The authors present a case of congestive cardiac failure and nephrotic range proteinuria in a patient with persistent fluid overload secondary toamyloid light-chain (AL) amyloidosis.

  • cardiovascular medicine
  • heart failure
  • nephrotic syndrome
  • acute renal failure
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Footnotes

  • Contributors JDSS: planning of report, conception of idea, detailed literature review, generation of first draft, critical revisions of manuscript to produce final edition; RK and DB: detailed literature review, generation of first draft, critical revisions of manuscript to produce final edition; MCB: planning of report, conception of idea, detailed critical revisions to manuscript to produce final edition.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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