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Angioedema as the presenting feature of systemic lupus erythematosus
  1. Naveen Kumar,
  2. Deepanjali Surendran,
  3. Chanaveerappa Bammigatti
  1. Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
  1. Correspondence to Dr Chanaveerappa Bammigatti, bammigatti{at}


A young female in her early 20s presented with low-grade fever for 1 month, puffiness of face and abdominal distension for 15 days. Evaluation revealed pancytopenia with normocellular marrow, hypocomplementaemia and Coomb’s positive haemolytic anaemia. She had angioedema with laryngospasm and worsening facial oedema which had dramatic response to steroids. Further workup lead to a diagnosis of systemic lupus erythematosus with neuropsychiatric involvement. Treatment with pulse steroids and cyclophosphamide resulted in dramatic improvement of her symptoms with no recurrence of angioedema during her follow-up visits.

  • systemic lupus erythematosus
  • immunology

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  • Contributors NK was managing the patient and prepared the initial manuscript. DS assisted in review of literature and manuscript preparation. CB is responsible for the overall management of the patient, manuscript submission and publication.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.