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CASE REPORT
Neuropsychological assessment as an objective tool to monitor treatment response in anti-N-methyl-D-aspartate receptor encephalitis
  1. Erica Sieg1,
  2. Michael Brook1,2,
  3. Jenny Linnoila3,
  4. Stephen VanHaerents4,5
  1. 1 Psychiatry and Behavioral Sciences, Northwestern Memorial Hospital, Chicago, Illinois, USA
  2. 2 Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
  3. 3 Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
  4. 4 Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
  5. 5 Department of Neurology, Northwestern Memorial Hospital, Chicago, Illinois, USA
  1. Correspondence to Dr Stephen VanHaerents, svanhaer{at}gmail.com

Summary

We report a 1-year follow-up of a young woman with anti-N-methyl-D-aspartate receptor encephalitis. Management of autoimmune encephalitis remains challenging as objective and clinically relevant biomarkers are sought, which allow for the monitoring of treatment response. While further investigation is required, we believe that this case highlights the importance of following a comprehensive neuropsychological profile as a clinically relevant biomarker to guide therapeutic decision-making. By relying on the neuropsychological assessment of the patient, treatment with more toxic medications was avoided and her antiepileptic drug regimen was simplified.

  • epilepsy and seizures
  • clinical neurophysiology
  • memory disorders (psychiatry)
  • immunology

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Footnotes

  • Contributors ES prepared the manuscript and performed the neuropsychological assessments. MB supervised ES neuropsychological assessments and critically reviewed the manuscript. JL provided clinical guidance to this case and critically reviewed the manuscript. SVH supervised the project, clinically manages the patient and critically reviewed the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests SV reports other from SAGE Therapeutics, outside the submitted work; Clinical Trial for super refractory status epileptics.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.