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Leptomeningeal carcinomatosis as primary presentation of metastatic urothelial cancer
  1. Jonathan Lambird1,
  2. Lucas Beerepoot2
  1. 1Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
  2. 2Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA
  1. Correspondence to Dr Jonathan Lambird, jlambird{at}


Leptomeningeal spread of carcinoma, referred to here as leptomeningeal carcinomatosis, is an uncommon complication of many cancer types. Its manifestations as the presenting symptoms of a new cancer diagnosis is even less common. This case describes the manifestations of leptomeningeal spread of urothelial carcinoma with review of pathophysiology driving the presenting symptoms of hypertension and headache. In the Discussion section, we address the standard and novel interventions for management of increased intracranial pressure.

  • hypertension
  • headache (including migraines)
  • neurooncology
  • urological cancer
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  • Contributors JL contributed to planning, data acquisition and review of literature. LB contributed to conception, reporting and design of documentation.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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