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Novel MRI of mediastinal masses: internal differentiation of a thymoma and lymphoma with T1 and T2 mapping
  1. Tanvi Karnik1,
  2. Rhiannon McBean2,
  3. Graeme Hart3,
  4. Katrina Newbigin2
  1. 1Department of Medicine, Bond University, Gold Coast, Queensland, Australia
  2. 2Wesley Medical Imaging, The Wesley Hospital, Auchenflower, Queensland, Australia
  3. 3Cardiothoracic Department, The Wesley Hospital, Auchenflower, Queensland, Australia
  1. Correspondence to Dr Rhiannon McBean, research{at}


Routine imaging for mediastinal malignancies includes chest X-ray, CT or MRI. T1 and T2 mapping are novel MRI techniques which may have a role in expanding the assessment of internal tumour characteristics. This case report details two middle-aged women who had similar clinical presentations of mediastinal masses of comparable size and appearance when assessed with routine imaging. T1 and T2 maps were acquired on MRI to investigate whether these tumours could be further differentiated prior to surgery. T1 and T2 mapping supported suspicion for which tumour components were solid and cystic, as subsequently confirmed histologically. Furthermore, comparison between the two tumours showed native T1 values differed within the solid components by 37%, correlating to differences in proteinaceous material within the tumour types. This radiological–pathological correlation provides evidence that T1 and T2 mapping has clinical utility in the assessment and differentiation of mediastinal masses.

  • radiology
  • oncology
  • pathology
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  • Contributors KN and GH designed this research study and acquired the data. All authors contributed to analysis of the results. TK and RM wrote the manuscript with input from all authors. All authors have approved the final version of this manuscript and agree to be accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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