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Heart transplant recipient with mycophenolate mofetil-induced colitis: the great imitator
  1. Obada Tayyem1,
  2. Hamzeh Saraireh1,
  3. Muhannad Al Hanayneh2,
  4. Heather L Stevenson3
  1. 1Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
  2. 2Department of Gastroenterology and Hepatology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
  3. 3Department of Pathology, University of Texas Medical Branch Institute for the Medical Humanities, Galveston, Texas, USA
  1. Correspondence to Dr Heather L Stevenson, hlsteven{at}


In this article, we report a case of a 55-year-old male heart transplant recipient who presented with diarrhoea. An extensive workup for infectious diseases was negative. The patient had a colonoscopy with biopsies showing colitis that mimicked graft-versus-host disease on histopathology. After excluding other potential causes and excluding acute cellular rejection, mycophenolate mofetil was discontinued, and the patient had significant clinical improvement with increased appetite and weight gain.

  • endoscopy
  • transplant
  • colitis

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  • Contributors OT and HS wrote the manuscript and reviewed the literature. MAH and HLS critically revised the manuscript for important intellectual content, supervised the process and approved the final draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.