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Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
CASE REPORT
High-dose thiamine and essential tremor
  1. Antonio Costantini
  1. Department of Neurology, Villa Immacolata, Viterbo, Italy
  1. Correspondence to Dr Antonio Costantini, carapetata{at}libero.it

Summary

Essential tremor is a common neurological disease. The medical treatment of this affection currently involves the use of propranolol, primidone and other drugs. These drugs, however, are often not effective in reducing tremor and cause side effects in a large share of the patients treated. The treatment with intramuscular high-dose thiamine has led to a rapid, remarkable and persistent improvement of the symptoms in two patients with essential tremor. This result suggests the possibility that high doses of intramuscular thiamine may be an affordable alternative, highly effective and long-lasting medical treatment that has shown no relevant side effect.

  • movement disorders (other than Parkinsons)
  • brainstem / cerebellum

https://doi.org/10.1136/bcr-2017-223945

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    Footnotes

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.