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Varicella-zoster virus necrotising retinitis, retinal vasculitis and panuveitis following uncomplicated chickenpox in an immunocompetent child
  1. Jonathan Yu1,
  2. Jane Ashworth2,
  3. Stephen Hughes3,
  4. Nicholas Jones1
  1. 1Manchester Royal Eye Hospital, Manchester, UK
  2. 2Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, UK
  3. 3Royal Manchester Children’s Hospital, Manchester, UK
  1. Correspondence to Professor Nicholas Jones, nicholas.jones{at}


A 4-year-old girl presented with acute left visual loss 4 weeks after uneventful chickenpox. She was found to have left necrotising retinitis and profound retinal vasculitis and vitritis. Aqueous humour was PCR positive for varicella-zoster virus. Combined intravenous and intravitreal antiviral treatment led to rapid improvement with settled retinitis, no vascular occlusion and good recovery of vision. Her recent coinfection with Epstein-Barr virus may have acted to provoke the retinitis.

  • infectious diseases
  • retina

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  • Contributors All authors were involved in the care of the patient. JY and NJ performed a literature search and cowrote the manuscript. JA and SH contributed to the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained,

  • Provenance and peer review Not commissioned; externally peer reviewed.