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CASE REPORT
Focal segmental glomerulosclerosis in a patient with prefibrotic primary myelofibrosis
  1. Gopal Krishana Bohra1,
  2. Durga Shankar Meena1,
  3. Nitin Bajpai2,
  4. Abhishek Purohit3
  1. 1Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, India
  2. 2Department of Nephrology, All India Institute of Medical Sciences, Jodhpur, India
  3. 3Department of Pathology, All India Institute of Medical Sciences, Jodhpur, India
  1. Correspondence to Dr Gopal Krishana Bohra, gopalbohra17{at}gmail.com

Summary

We report a case of 56-year-old man presented to us with chief complaints of frothy urine and leg swelling. A urinalysis revealed nephrotic-range proteinuria. Haematological investigations revealed thrombocytosis, leucocytosis and peripheral blood smear showed a leucoerythroblastic picture. JAK 2 mutation was positive. To confirm the diagnosis of myeloproliferative neoplasm, bone marrow biopsy was done, which was suggestive of primary myelofibrosis. The patient underwent kidney biopsy due to rapidly declining renal function and persistent proteinuria, which was suggestive of focal segmental glomerulosclerosis. Early glomerulopathy is rare in myeloproliferative neoplasm, and aggressive follow-up is required to prevent progression of kidney disease.

  • malignant and benign haematology
  • renal system
  • proteinurea
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Footnotes

  • Contributors DSM and GKB for concept, design and drafting of manuscript. AP and NB for analysis and critical revision. All authors approved the final version of manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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