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CASE REPORT
Autoimmune autonomic ganglionopathy associated with Sjögren’s syndrome presenting with recurrent abdominal distension
  1. Takeshi Yoshida1,
  2. Mitsuyo Kinjo2,
  3. Shunya Nakane3
  1. 1Rheumatology, Chikamori Byoin, Kochi, Japan
  2. 2Rheumatology, Okinawa Chubu Hospital, Uruma, Japan
  3. 3Molecular Neurology and Therapeutics, Kumamoto University Hospital, Kumamoto, Japan
  1. Correspondence to Dr Mitsuyo Kinjo, kinjomitsuyo{at}gmail.com

Summary

A 65-year-old woman with Sjögren’s syndrome presented with recurrent abdominal distension, constipation, weight loss, orthostatic dizziness, loss of sweating and incomplete emptying of the bladder. Gastrointestinal dilatation but no evidence of malignancy or obstruction was found on CT of the abdomen, oesophagogastroduodenoscopy or colonoscopy. Postvoiding residual urine volume was increased. Antiganglionic acetylcholine receptor antibody was positive. We diagnosed as autoimmune autonomic ganglionopathy. The patient responded to corticosteroid treatment. One year after treatment, she continued to have mild gastrointestinal symptoms, but overall condition was stable without further intervention.

  • neurogastroenterology
  • sjogren’s syndrome

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Footnotes

  • Contributors All authors certify that they have participated sufficiently in the work to take public responsibility for the content, including participation in the concept, design, analysis, writing or revision of the manuscript. MK: conception and design, acquisition of data, interpretation of data, drafting and revising the article and final approval of the version published. TY: conception and design, acquisition of data, interpretation of data, draftng and revising the article and final approval of the version published. SN: conception and design, analysis of data, acquisition of data, interpretation of data, revising the article and final approval of the version published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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