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CASE REPORT
Eosinophilic angiocentric fibrosis : a sino-orbital masquerader
  1. Nicole Legare1,
  2. Seema Frosh2,
  3. Jonathan B Vasquez3,
  4. Son T Ho4
  1. 1University of Central Florida, College of Medicine, Orlando, Florida, USA
  2. 2Rheumatology, Orlando VA Medical Center, Orlando, Florida, USA
  3. 3Pathology, Orlando VA Medical Center, Orlando, Florida, USA
  4. 4Ophthalmology, Orlando VA Medical Center, Orlando, Florida, USA
  1. Correspondence to Dr Nicole Legare, nicolespitzer{at}knights.ucf.edu

Summary

A 58-year-old Caucasian male presented with left periorbital oedema extending to the nasal area for 1 year along with nasal discharge for 1 month. Lab work was significant for positive cytoplasmic antineutrophil cytoplasmic antibodies. CT scan showed solid mass along the nasal soft tissue with bony nasal destruction. A CT scan of the thorax was performed to rule out granulomatosis with polyangiitis and showed multiple pulmonary nodules. Biopsies of the nasal mass and lung nodule were performed which showed fragments of fibrosis with spindle cell proliferation consistent with eosinophilic angiocentric fibrosis (EAF). EAF is a very rare disease, recently described as a subtype of immunoglobulin G4-related disease. A few rare cases of EAF involving the structures of the orbit have been reported in the literature.

  • ophthalmology
  • rheumatology
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Footnotes

  • Contributors All authors contributed to the planning, work and research pertaining to this article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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