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Antenatal chemotherapy in a case of diffuse large B-cell lymphoma
  1. Akhil Rajendra1,
  2. Anup J Devasia2,
  3. Nirmal Raj Francis1,
  4. Vijay Prakash Turaka1
  1. 1Department of Internal Medicine, Christian Medical College, Vellore, Tamilnadu, India
  2. 2Department of Haematology, Christian Medical College, Vellore, Tamilnadu, India
  1. Correspondence to Dr Akhil Rajendra, akhilrk1989{at}


A 28-year-old pregnant woman in the sixth month of gestation presented with complaints of altered bowel habit for a month, on examination found to have generalised lymphadenopathy, pedal oedema and locally infiltrating ano-rectal growth. Rectal growth biopsy was reported as high-grade B-cell lymphoma. After a discussion in a multidisciplinary panel consisting of haemato-oncologists, obstetricians and physicians, she was planned to receive antenatal chemotherapy. She delivered a live baby of 1.86 kg at 36 weeks of gestational age by normal vaginal delivery. After 6 cycles of chemotherapy she had complete regression of the disease.

  • malignant and benign haematology
  • cancer intervention
  • haematology (drugs and medicines)
  • obstetrics, fynaecology and fertility

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  • Contributors AR and NRF were involved in the primary evaluation of the patient. AR, AJD and VPT were involved in the conception and drafting of the case report, reviewing existing literature and revising the report. AR is a guarantor.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.