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Recurrent postinfectious glomerulonephritis: an unusual evolution compatible with C3 glomerulopathy
  1. Jose Luis Espinosa-Figueroa1,
  2. Marta Cano-Megías1,
  3. Patricia Martínez-Miguel1,
  4. Mercedes Velo-Plaza2
  1. 1Nephrology, Hospital Universitario Principe de Asturias, Alcala de Henares, Spain
  2. 2Nephrology, Hospital Clínico Universitario San Carlos, Madrid, Spain
  1. Correspondence to Dr Patricia Martínez-Miguel, pmmiguel{at}


Acute endocapillary glomerulonephritis, as its name suggests, is a one-time process, which usually resolves within weeks. However, in a small percentage of patients, the disease becomes chronic. In these cases, a deregulation in the alternative complement pathway, which can be caused by mutations or autoantibodies, has been proposed as a pathophysiological mechanism. As a result, the alternative complement pathway remains active after resolution of infection. We report a patient with two episodes of acute renal failure, both times diagnosed by renal biopsy of acute endocapillary glomerulonephritis, with slow recovery after two episodes of low-serum complement C3, haematuria and proteinuria.

  • acute renal failure
  • proteinurea
  • hematuria
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  • Contributors All the authors have contributed to carry out this work; JLE-F, MC-M have written the manuscript, with supervision from PM-M and MV-P.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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