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Cisplatin-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) with life-threatening hyponatraemia
  1. Aaron C. Tan1,
  2. Gavin M. Marx2
  1. 1Department of Medical Oncology, Royal North Shore Hospital, St Leonards, New South Wales, Australia
  2. 2SAN Integrated Cancer Centre, Sydney Adventist Hospital, Wahroonga, New South Wales, Australia
  1. Correspondence to Dr Aaron C. Tan, tan.aaron.c{at}


We present a case of cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with metastatic recurrent urothelial carcinoma. Cisplatin-induced SIADH is an uncommon but potentially life-threatening toxicity. Pharmacogenetic characteristics may result in different toxicity profiles in different populations. With such widespread use of cisplatin in a diverse range of cancers, prompt recognition is crucial to detect and prevent severe neurological sequelae.

  • chemotherapy
  • urological cancer
  • unwanted effects / adverse reactions
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  • Contributors AT and GM: identification of case, clinical interaction, preparation of the manuscript and proof-reading.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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