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- venous thromboembolism
- emergency medicine
- ulcerative colitis
- epilepsy and seizures
- headache (including migraines)
We present a complex diagnosis of a 25-year-old woman with a background of ulcerative colitis (UC) at risk of both intracranial haemorrhage and thrombosis.
The patient presented to the emergency department having collapsed at work, obtaining a head injury while falling to the floor and suffering an 8 min seizure in the immediate aftermath. The patient had an acute flare of her UC 2 weeks previously, and her medical history included a deep vein thrombosis following a long-haul flight and a pulmonary embolism while taking contraceptive pill/oral contraceptives.
The patient denied a headache preceding her collapse, although she admitted her head had ‘felt fuzzy’ during the previous 2 days. CT of the head was performed (figure 1A,B), revealing patchy haemorrhagic changes in the right frontal lobe. Abnormal hyperdensity of the superior sagittal sinus and of a cortical vein was also noted; the patient underwent MRI of the head and CT venography, confirming intracranial thrombosis with substantial surrounding oedema (figures 2 and 3). The patient was consequently given a heparin infusion.
Although a head injury can cause intracranial haemorrhage, our patient had multiple risk factors for thrombosis (UC with recent flare, previous deep vein thrombosis and pulmonary embolism)1 ,2 which, combined with an unusual pattern of intracranial haemorrhage on CT, triggered consideration of the alternative diagnosis of intracranial thrombosis, in which associated haemorrhage is a feature in 30%–40% of cases.
Ulcerative colitis is an independent risk factor for venous thrombosis with a lifetime incidence of around 6%.
Venous infarction secondary to cerebral venous thrombosis appears as intracranial haemorrhage on imaging in 30%–40% of cerebral venous thrombosis.
Plain CT head images provide a diagnosis of cerebral venous thrombosis in approximately 30% of cases; in the event of a normal CT head, diagnostic suspicion must guide appropriate further imaging such as CT/magnetic resonance venography.
Contributors JD drafted the case and revised it critically for important intellectual content. RB reviewed the drafted manuscript, revised it critically for important intellectual content and obtained patient consent.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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