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A child with tubulointerstitial nephritis and uveitis (TINU) syndrome
  1. Cátia Pereira1,
  2. Patrícia Costa-Reis2,
  3. José Esteves da Silva2,
  4. Rosário Stone2
  1. 1Departamento de Pediatria, Hospital de Santa Maria - Centro Hospitalar de Lisboa Norte, Lisboa, Portugal
  2. 2Unidade de Nefrologia e Transplantação Renal Pediátrica, Departamento de Pediatria, Hospital de Santa Maria - Centro Hospitalar de Lisboa Norte, Lisboa, Portugal
  1. Correspondence to Dra. Cátia Pereira, catiamrpereira{at}


Tubulointerstitial nephritis and uveitis syndrome is an uncommon disease, probably underdiagnosed in clinical practice. Its aetiology and pathogenesis remain unknown. This syndrome is defined by an association of uveitis and tubulointerstitial nephritis, with no evidence of systemic disease or infection that might cause both ocular and renal inflammation. Renal and ocular manifestations may not occur simultaneously, making the diagnosis even more challenging. Treatment includes topical and oral corticosteroids. Renal involvement usually resolves spontaneously with full recovery of kidney function, however uveitis can persist or recur years after its initial presentation. We report a case of a 13-year-old girl with tubulointerstitial nephritis and uveitis syndrome.

  • proteinurea
  • acute renal failure
  • fluid electrolyte and acid-base disturbances
  • anterior chamber
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  • Contributors CP, PC-R, JEdS and RS conducted the analysis of the described case. CP drafted the manuscript. PC-R, JES and RS critically reviewed the manuscript. All the authors read and approved the final version.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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