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CASE REPORT
An 88-year-old woman with flushing, alopecia and hirsutism and a Sertoli-Leydig cell tumour
  1. Zaina S Inam1,
  2. Abdul Hussain Azizi1,
  3. Soemiwati W Holland2
  1. 1Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA
  2. 2Department of Endocrinology, Susquehanna Health System, Williamsport, Pennsylvania, USA
  1. Correspondence to Zaina S Inam, zaina.inam{at}gmail.com

Summary

Sertoli-Leydig cell tumour (SLCT) is a rare, androgen-secreting sex cord–stromal tumour of the ovary that usually occurs in young premenopausal women. The major clinical manifestations are virilisation and defeminisation. The following case describes an 88-year-old G1P1 woman, 40 years after menopause, who presented with flushing, hirsutism, voice changes and alopecia along with significantly elevated levels of testosterone. Postoperative report revealed a well-differentiated SLCT in the left ovary. This case is unique in that SLCT is a very rare cancer and even more so in an 88-year-old woman. Taking this case into consideration, it becomes reasonable to check androgen and oestrogen levels in postmenopausal women, not only in patients with signs of virilisation, but also in those with non-classical presentations, such as flushing or heat spells.

  • endocrinology
  • obstetrics and gynaecology
  • gynecological cancer

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Footnotes

  • Contributors ZSI and AHA: acquisition, analysis and interpretation of data; drafting and revising the manuscript critically for important intellectual content; approval of the final version of the manuscript to published. HS: acquisition of data; revising the manuscript critically for important intellectual content; approval of the final version of the manuscript to be published.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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