Article Text

PDF
CASE REPORT
Double invasive fungal infection due to dematiaceous moulds in a renal transplant patient
  1. Guy El Helou1,
  2. Elizabeth Palavecino2,
  3. Marina Nunez1
  1. 1Department of Infectious Diseases, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA
  2. 2Pathology Labs, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA
  1. Correspondence to Dr Guy El Helou, gelhelou{at}wakehealth.edu

Summary

Alternaria and Verruconis are two dematiaceous moulds that occasionally cause disease in immunocompromised hosts. We present the case of a 58-year-old man with history of deceased donor renal transplantation 14 months prior, who presented with fevers and cough. He was found to have right upper lobe pneumonia and a non-healing eschar of his right knee. Dematiaceous fungi grew from bronchoalveolar lavage (BAL) and was sent to reference lab for identification. Meanwhile, the eschar on his right knee was biopsied and grew Alternaria spp. Pathology was consistent with invasive mould infection and he was treated as having disseminated Alternaria infection with voriconazole and amphotericin B lipid complex. Later on, the dematiaceous mould from a BAL specimen was identified as Verruconis gallopava. The patient was discharged on voriconazole awaiting minimal inhibitory concentrations for V. gallopava but was readmitted 2 days later with high fevers and died from acute respiratory failure.

  • pneumonia (infectious disease)
  • renal transplantation
  • infections
  • malignant disease and immunosuppression

Statistics from Altmetric.com

Footnotes

  • Contributors GEH and MN: took part in caring for and treating patient with the infectious diseases department. EP: is head of the microbiology lab and offered great help in identifying the different molds. All authors: contributed in this manuscript through writing and editing.

  • Competing interests None declared.

  • Patient consent Guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.