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Granulomatosis with polyangiitis: an unusual cause of acute liver injury
  1. David Owen Rees1,
  2. Anu Gunavardhan2,
  3. David Andrew Glover3
  1. 1Nephrology and Transplant Department, Cardiff and Vale University Health Board, Cardiff, UK
  2. 2Pathology Department, BCU Health Board, Rhyl, UK
  3. 3Nephrology Department, BCU Health Board, Wrexham, UK
  1. Correspondence to Dr David Owen Rees, davidowenrees{at}


Granulomatosis with polyangiitis (GPA) causing liver injury is rare. Where liver biopsies have been taken findings are not always typical and diagnosis can be challenging. Here, we present a case of a 58-year-old male who on admission to hospital was found to have acute liver injury. Diagnosis of liver involvement in GPA is supported by liver histology and the resolution of hepatitis after commencement of immunosuppressive treatment.

  • renal system
  • immunology
  • acute renal failure
  • hepatitis other

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  • Contributors DOR conducted literature review and wrote case report. AG interpreted slides and provided images of slides. DAG supervised and edited case report.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.